Polysoaps with fluorocarbon hydrophobic chains

Synthesis and Characterization of Molecules to Study the Conformational Barriers in Fluorocarbon Chains

Interactions between amino acid side chains in cylindrical hydrophobic nanopores with applications to peptide stability.

Confinement effects on protein stability are relevant in a number of biological applications ranging from encapsulation in the cylindrical cavity of a chaperonin, translocation through pores, and structure formation in the exit tunnel of the ribosome. Consequently, free energies of interaction between amino acid side chains in restricted spaces can provide insights into factors that control pro...

An exceptional series of phase transitions in hydrophobic amino acids with linear side chains

The solid-state phase transitions and intermediate structures of S-2-amino-butanoic acid (l-2-aminobutyric acid), S-2-aminopentanoic acid (l-norvaline), S-2-aminohexanoic acid (l-norleucine) and l-methionine between 100 and 470 K, identified by differential scanning calorimetry, have been characterized in a comprehensive single-crystal X-ray diffraction investigation. Unlike other enantiomeric ...

The water-hydrophobic interface: neutral and charged solute adsorption at fluorocarbon and hydrocarbon self-assembled monolayers (SAMs).

Adsorption of small molecular solutes in an aqueous solution to a soft hydrophobic surface is a topic relevant to many fields. In biological and industrial systems, the interfacial environment is often complex, containing an array of salts and organic compounds in the solution phase. Additionally, the surface itself can have a complex structure that can interact in unpredictable ways with small...

Molecular origins of fluorocarbon hydrophobicity.

We have undertaken atomistic molecular simulations to systematically determine the structural contributions to the hydrophobicity of fluorinated solutes and surfaces compared to the corresponding hydrocarbon, yielding a unified explanation for these phenomena. We have transformed a short chain alkane, n-octane, to n-perfluorooctane in stages. The free-energy changes and the entropic components ...